Autoantigenic epitopes of Molecule X

This is a view of an autoantigen (self-antigen), specifically a protein autoantigen that mediates disease in patients having mutations in the gene that produces this molecule. A the protein level, the mutations give rise to conformation changes in the protein that reveal an otherwise cryptic epitope to antibody binding.

autoantigen, autoimmune, disease, epitope, molecular, antibody, conformation, cryptic, surface exposed, buried, change, dynamic, self-antigen