Molecular Animation of Phosphodiesterase type 5 (PDE5) Binding / Docking to Viagra

The phosphodiesterase type 5 inhibitor, Viagra ^TM (Sildenafil), is shown to bind to phosphodiesterase type 5 (PDE5).

Part of the physiological process of erection involves the release of nitric oxide (NO) in vasculature of the corpus cavernosum. NO activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in blood vessels supplying the corpus cavernosum, resulting in increased inflow of blood and an erection.

PDE5 inhibitors inhibit the degradation of cGMP by phosphodiesterase type 5 (PDE5), increasing bloodflow to the penis during sexual stimulation.

View a molecular animation of Viagra/Sildenafil binding to PDE5 (Movie size: 16.6MB). With scientific accuracy, the binding pocket opens up to allow the drug to bind to the enzyme. Read more about molecular animations.

View other Viagra/PDE5-related porfolio entries:
Viagra and Phosphodiesterase 5 Complex
Viagra - Sildenafil citrate

Phosphodiesterase type 5, PDE5, viagra, Sildenafil, inhibitor, drug, binding, image, illustration, graphics, photograph, cyclic GMP, smooth muscle, cells, blood, erectile dysfunction, nitric oxide, NO, guanylate cyclase, mode of action, binding, animation